Non-cardiac Chest Pain (NCCP)

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NCCP Overview

• What is non-cardiac chest pain?
  • Non-cardiac chest pain (NCCP) is chest pain in patients who do not have heart disease as the cause.
  • The pain can be felt behind the breastbone. It can be squeezing or pressure-like. It may extend to the neck, left arm or the back.
  • The pain may be caused by eating or drinking.
  • It can last from a few seconds or minutes to many hours.
  • Patients may have other symptoms such as heartburn or regurgitation.
  • Because NCCP may feel similar to heart pain, patients should ask their doctor to exclude heart disease.
• Why is cardiac and NCCP similar?
  • The heart and the food pipe (esophagus) are located next to each other in the chest (Figure 1).
  • Because the same nerves travel through both the heart and the esophagus, pain from either organ can feel similar.
  • A very common source of NCCP is from the esophagus.

  

  Figure 1. The heart and the esophagus are located next to each other in the chest and also share the same nerves.

Causes

• What are the causes of NCCP?

  NCCP can be due to disorders of the esophagus. It can also be due to parts of the body outside of the esophagus.

  1. Causes of NCCP due to the esophagus:
  • Acid Reflux (GERD)
  • The most common cause of NCCP is acid reflux.
  • 20-60% of patients with NCCP suffer from acid reflux.
  • Patients may also have heartburn or regurgitation.
  • Muscle disorders of the esophagus:
  • When the muscles of the esophagus do not work properly, it can cause NCCP. Examples include:
  • Muscle spasms
  • High pressure squeezing of the esophageal muscles
  • Esophageal muscles that do not work at all due to a loss of nerve cells (achalasia). It is important to diagnose achalasia since it can be treated, usually with some type of surgery.
  • Sensitive esophagus:
  • Patients with NCCP may have a esophagus that is sensitive. This means that small changes in pressure or acid (from eating or drinking) may cause pain.
  • Although the cause of this higher sensitivity is not always clear, there are ways to treat it by lowering the nerve signals from the GI tract.
  2. Causes of NCCP outside of the esophagus:
  • Bone and muscle disorders of the chest wall or back
  • Lung disorders
  • Disorders of the layers of tissue that cover the lungs
  • Disorders of the layer of tissue that protects the heart
  • Ulcers in the stomach
  • Gallbladder disorders
  • Pancreas disorders
  • Tumors (more so in patients past age 50)
  3. The Role of Stress
  • Some patients with NCCP also suffer from stress that leads to depression, anxiety or panic attacks.
  • It is not known whether the stress came first or the chest pain led to the changes in mood. Treatment of these conditions is an important part of treating NCCP.

Risk Factors

• What are the risk factors for NCCP?
  • NCCP can occur in kids as well as older adults.
  • It affects both men and women. NCCP may be more common in women, but the reasons why are not well known.
  • NCCP is a very common problem that occurs globally.
  • 70 million patients in the U.S. suffer from NCCP.
  • No other specific risk factors have been found.

Diagnosis

• What do I do if I’ve been treated for chest pain, but told I didn’t have a heart attack?
  • Heart diseases should be ruled out before being diagnosed with NCCP.
  • A common first treatment for NCCP are acid blocking drugs. These are called proton pump inhibitors (PPIs). If taking 2 weeks of PPIs improves the chest pain, then acid reflux is the likely cause.
  • If NCCP is improved by PPIs, the treatment can be used for longer (2 months).
  • If the patient does not improve after taking PPIs, further testing may be done to:
  • Look inside the esophagus and stomach with a camera procedure called an endoscopy
  • Measure acid levels in the esophagus
  • Measure how well the esophageal muscles squeeze
  • Image other organs in the chest and abdomen

Treatment

• What are the treatments for NCCP?
  1. Patients may be treated as if the NCCP was due to acid reflux:
  • Acid blocking drugs called proton pump inhibitors (PPIs) can be used to treat NCCP, since the most common cause of NCCP is acid reflux.
  • PPIs should be taken 30 minutes before breakfast for 2 weeks. About 80% of patients with NCCP due to GERD feel better after trying PPIs.
  • If the patient improves, the treatment can be continued for several months.
  2. For patients who don’t improve after taking PPIs, GERD may not be their source of NCCP:
     • It is important to know that other treatments are available. These drugs act on the nerves that travel through the esophagus to reduce pain.
     • These drugs can also be used to treat depression, anxiety or panic attacks. The doses used for NCCP are much lower.
  3. Treating stress:
     • If patients do not feel better with the above treatments, or they suffer from depression, anxiety, or panic attacks, they should seek further help. This may include seeing a psychiatrist.
     • Talk therapy, hypnosis, and coping skills training can improve NCCP.
     • New studies are being done to find new treatments for NCCP.

Author(s) and Publication Date(s)

Sami R. Achem, MD, FACG, Mayo College of Medicine, Mayo Clinic, Jacksonville, FL – Published February 2009. Updated July 2013.

Jennifer X. Cai, MD, MPH, Brigham and Women's Hospital, Boston, MA – Updated June 2022.

Nimrod Deiss-Yehiely, MD, University of Chicago, Chicago, IL – Updated April 2026.

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